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rdf:type |
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lifeskim:mentions |
umls-concept:C0007786,
umls-concept:C0017837,
umls-concept:C0019564,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035124,
umls-concept:C0205263,
umls-concept:C0205374,
umls-concept:C0270611,
umls-concept:C0443324,
umls-concept:C0475224,
umls-concept:C0598958,
umls-concept:C0796516,
umls-concept:C1134558,
umls-concept:C1548559,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
In this study, we investigated the effect of GST, an extract of Chinese traditional herb, on transient brain ischemia/reperfusion-induced neuronal cell death. Immunoblotting was used to detect the phosphorylation of MLK, JNK and c-jun. Transient (15 minutes) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. GST was administrated to the SD rats 20 minutes before ischemia or 1 hour after ischemia. Our data showed that the pretreatment of GST could inhibit phosphorylation of MLK, JNK and c-jun. Moreover, GST showed potent neuroprotective effects on ischemic brain damage in vivo and administration of it 1 hour after ischemia also achieved the protective effects. These results indicate that GST has a prominent neuroprotection action against brain ischemic damage and provides a promising therapeutic approach for ischemic brain injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0161-6412
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18953737-Animals,
pubmed-meshheading:18953737-Brain Injuries,
pubmed-meshheading:18953737-Brain Ischemia,
pubmed-meshheading:18953737-Cell Death,
pubmed-meshheading:18953737-Dose-Response Relationship, Drug,
pubmed-meshheading:18953737-Drugs, Chinese Herbal,
pubmed-meshheading:18953737-Hippocampus,
pubmed-meshheading:18953737-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:18953737-MAP Kinase Kinase Kinases,
pubmed-meshheading:18953737-Male,
pubmed-meshheading:18953737-Neuroprotective Agents,
pubmed-meshheading:18953737-Phosphorylation,
pubmed-meshheading:18953737-Rats,
pubmed-meshheading:18953737-Rats, Sprague-Dawley,
pubmed-meshheading:18953737-Reperfusion Injury,
pubmed-meshheading:18953737-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Neuroprotection of GST, an extract of traditional Chinese herb, against ischemic brain injury induced by transient brain ischemia and reperfusion in rat hippocampus.
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pubmed:affiliation |
Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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