Linked Life Data

18953671

Source:http://linkedlifedata.com/resource/pubmed/id/18953671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-11-4
pubmed:abstractText
This study ascertains the effects of zinc, a major component of particulate matter, on pulmonary and systemic endpoints using hyperlipidemic rabbits to model diet-induced human atherosclerosis. New Zealand White rabbits were fed a normal or cholesterol-enriched diet and then were intratracheally instilled 1x/week for 4 weeks with saline or 16 microg/kg of zinc, equal parts sulfate and oxide. Physiologic responses, blood after each exposure, and terminal bronchoalveolar lavage (BAL) were assessed. Rabbits fed a cholesterol-rich diet developed hyperlipidemia and had consistently higher circulating leukocyte counts than rabbits fed normal chow. Within minutes after zinc instillation, saturation of peripheral oxygen was decreased in hyperlipidemic rabbits and heart rate was increased in hyperlipidemic rabbits with total serum cholesterol levels greater than 200 mg/dl. Total circulating leukocytes levels were increased 24 h after the first zinc instillation, but upon repeated exposures this effect was attenuated. After repeated zinc exposures, BAL fluid (BALF) N-acetylglucosaminidase activity was increased regardless of hyperlipidemic state. Hyperlipidemic rabbits had an increase in BALF-oxidized glutathione and a decrease in serum nitrite. The study elucidates mechanisms by which the zinc metal component of PM drives cardiovascular health effects, as well as the possible susceptibility induced by hyperlipidemia. Furthermore, the study exemplifies the benefits of monitoring circulatory physiology during exposure as well as after exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1559-0259
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-206
pubmed:meshHeading
pubmed-meshheading:18953671-Acetylglucosaminidase, pubmed-meshheading:18953671-Animals, pubmed-meshheading:18953671-Atherosclerosis, pubmed-meshheading:18953671-Bronchoalveolar Lavage Fluid, pubmed-meshheading:18953671-Cholesterol, pubmed-meshheading:18953671-Disease Models, Animal, pubmed-meshheading:18953671-Dose-Response Relationship, Drug, pubmed-meshheading:18953671-Glutathione Disulfide, pubmed-meshheading:18953671-Heart Rate, pubmed-meshheading:18953671-Hyperlipidemias, pubmed-meshheading:18953671-Inhalation Exposure, pubmed-meshheading:18953671-Intubation, Intratracheal, pubmed-meshheading:18953671-Leukocyte Count, pubmed-meshheading:18953671-Lung, pubmed-meshheading:18953671-Male, pubmed-meshheading:18953671-Nitrites, pubmed-meshheading:18953671-Particulate Matter, pubmed-meshheading:18953671-Rabbits, pubmed-meshheading:18953671-Zinc Oxide, pubmed-meshheading:18953671-Zinc Sulfate
pubmed:year
2008
pubmed:articleTitle
A hyperlipidemic rabbit model provides new insights into pulmonary zinc exposure effects on cardiovascular health.
pubmed:affiliation
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. lagier.adriana@epa.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.