Source:http://linkedlifedata.com/resource/pubmed/id/18953659
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2008-11-17
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pubmed:abstractText |
The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normoglycemics treated with vitamin E (NE), diabetics (D), and diabetics treated with vitamin E (DE). Quantitative and morphometric analyses were performed. The area of the tertiary plexus was also determined. Diabetes produced a 24% reduction in the number of myosin-V neurons in group D compared with group N, an effect that was accompanied by an increase in the tertiary plexus area (P < 0.05). Neuronal density was 27% higher in group NE than group N (P < 0.05). Nitrergic neuronal density was not altered as a consequence of either diabetes or vitamin E treatment. Myosin-V and nNOS immunoreactive neuronal cell body area increased significantly in group NE. The area of myosin-V and nNOS myenteric neurons also increased in group D. Vitamin E treatment (group DE) increased only the size of nitrergic neurons. The present results suggest that vitamin E elicited a neuroprotective and neurotrophic effect on the natural aging process, but with regard to diabetes, vitamin E supplementation exerted a neurotrophic effect only on nitrergic neurons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Type V,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1567-2379
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-603
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pubmed:meshHeading |
pubmed-meshheading:18953659-Animals,
pubmed-meshheading:18953659-Antioxidants,
pubmed-meshheading:18953659-Diabetes Mellitus, Experimental,
pubmed-meshheading:18953659-Dietary Supplements,
pubmed-meshheading:18953659-Humans,
pubmed-meshheading:18953659-Ileum,
pubmed-meshheading:18953659-Male,
pubmed-meshheading:18953659-Myenteric Plexus,
pubmed-meshheading:18953659-Myosin Type V,
pubmed-meshheading:18953659-Neurons,
pubmed-meshheading:18953659-Neuroprotective Agents,
pubmed-meshheading:18953659-Nitric Oxide Synthase Type I,
pubmed-meshheading:18953659-Rats,
pubmed-meshheading:18953659-Rats, Wistar,
pubmed-meshheading:18953659-Vitamin E
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pubmed:year |
2008
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pubmed:articleTitle |
Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum.
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pubmed:affiliation |
Department of Morphophysiological Sciences, Universidade Estadual de Maringá, Avenida Colombo, no. 5790 Bloco H-79, CEP 87020-900 Maringá, PR, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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