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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0011860,
umls-concept:C0017337,
umls-concept:C0085580,
umls-concept:C0240293,
umls-concept:C0441587,
umls-concept:C0681850,
umls-concept:C1442161,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
6
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% vs. 29.33%; P-=0.029) and in hypertensive with T2DM subjects (46.15% vs. 29.33%; P=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-10404816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-10509541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-10734146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-11056163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-11302910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-11345359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-11753579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-12629104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-14744925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-14976578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-15309292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-15660746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-15808811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-16247508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-16269962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-17039423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-17981310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-18360038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-2164221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-4337382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-7619352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-8098595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953403-8641026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1449-2288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18953403-Adult,
pubmed-meshheading:18953403-Aged,
pubmed-meshheading:18953403-Case-Control Studies,
pubmed-meshheading:18953403-Diabetes Mellitus, Type 2,
pubmed-meshheading:18953403-Female,
pubmed-meshheading:18953403-Gene Frequency,
pubmed-meshheading:18953403-Genotype,
pubmed-meshheading:18953403-Humans,
pubmed-meshheading:18953403-Hypertension,
pubmed-meshheading:18953403-INDEL Mutation,
pubmed-meshheading:18953403-Malaysia,
pubmed-meshheading:18953403-Male,
pubmed-meshheading:18953403-Middle Aged,
pubmed-meshheading:18953403-Receptors, Adrenergic, alpha-2
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pubmed:year |
2008
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pubmed:articleTitle |
Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects.
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pubmed:affiliation |
Molecular Biology Lab, Department of Biomedical Science, Universiti Putra Malaysia, Serdang 43400, Malaysia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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