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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-2
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pubmed:abstractText |
Recent advances in understanding beta-catenin-independent WNT (non-canonical) signalling suggest an increasing complexity, raising the question of how individual non-canonical pathways are induced and regulated. Here, we examine whether intracellular signalling components such as beta-arrestin (beta-arr) and casein kinases 1 and 2 (CK1 and CK2) can contribute to determining signalling specificity in beta-catenin-independent WNT signalling to the small GTPase RAC-1. Our findings indicate that beta-arr is sufficient and required for WNT/RAC-1 signalling, and that casein kinases act as a switch that prevents the activation of RAC-1 and promotes other non-canonical WNT pathways through the phosphorylation of dishevelled (DVL, xDSH in Xenopus). Thus, our results indicate that the balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-11171997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-11437444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-11472835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-11677610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-12137734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-12533515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-12694202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-14722104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-15143170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-15297873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-15748172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-16672224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-16824921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-16824922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17027228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17079465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17244647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17336901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17426148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17476309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17488628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-17620599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-18160045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18953287-9214626
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1469-3178
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1244-50
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18953287-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18953287-Animals,
pubmed-meshheading:18953287-Arrestins,
pubmed-meshheading:18953287-Casein Kinase I,
pubmed-meshheading:18953287-Casein Kinase II,
pubmed-meshheading:18953287-Cell Line,
pubmed-meshheading:18953287-Embryo, Nonmammalian,
pubmed-meshheading:18953287-Enzyme Activation,
pubmed-meshheading:18953287-Gastrulation,
pubmed-meshheading:18953287-Humans,
pubmed-meshheading:18953287-Mice,
pubmed-meshheading:18953287-Phosphoproteins,
pubmed-meshheading:18953287-Signal Transduction,
pubmed-meshheading:18953287-Wnt Proteins,
pubmed-meshheading:18953287-Xenopus,
pubmed-meshheading:18953287-rac1 GTP-Binding Protein
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pubmed:year |
2008
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pubmed:articleTitle |
Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.
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pubmed:affiliation |
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Scheeles v ag 1, S-171 77 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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