rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
The antiproliferative mechanisms of flavonoid drugs inpancreatic cancer cells remain unclear. In this study, we evaluated the effects of the flavonoid apigenin on glucose uptake, on the expression of the glucose transporter 1 (GLUT-1), and on the phosphoinositide 3-kinase (PI3K)/Akt pathway in human pancreatic cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKTIP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apigenin,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SLC2A1 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1536-4828
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
426-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18953257-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18953257-Antineoplastic Agents,
pubmed-meshheading:18953257-Apigenin,
pubmed-meshheading:18953257-Apoptosis Regulatory Proteins,
pubmed-meshheading:18953257-Cell Line, Tumor,
pubmed-meshheading:18953257-Dose-Response Relationship, Drug,
pubmed-meshheading:18953257-Glucose Transporter Type 1,
pubmed-meshheading:18953257-Humans,
pubmed-meshheading:18953257-Pancreatic Neoplasms,
pubmed-meshheading:18953257-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18953257-Protein Kinase Inhibitors,
pubmed-meshheading:18953257-RNA, Messenger,
pubmed-meshheading:18953257-Signal Transduction,
pubmed-meshheading:18953257-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/Akt pathway in human pancreatic cancer cells.
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pubmed:affiliation |
Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. lgolkar@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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