Linked Life Data

18951958

Source:http://linkedlifedata.com/resource/pubmed/id/18951958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-11-25
pubmed:abstractText
Transmissible spongiform encephalopathies (TSE) is a group of diseases that is unique in comprising disorders that can occur sporadically, are hereditary and/or infectious. The transmissible pathogen--the prion--is distinct from all other pathogens in being devoid of nucleic acids. During the elucidation of these disorders, many different--and contradictory--theories have been put forward. Early researchers, mostly driven by the economic impact of these diseases on sheep farming, engaged in heavy disputes concerning heredity vs. infectivity of scrapie. Following the experimental demonstration of scrapie's infectivity during the 20th century, research focused on the characterization of the nature of the transmissible agent. The current work comprehensively summarizes the available early literature on TSE research. A review of the historical literature is presented, describing the efforts in breeding, transmission experiments, and theories about the nature of the infectious agent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-2747
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-55
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The early history of the transmissible spongiform encephalopathies exemplified by scrapie.
pubmed:affiliation
Department of Operative and Preventive Dentistry, Heinrich-Heine-University/Westdeutsche Kieferklinik, Moorenstrasse 5, Building 18.13, D-40225 Düsseldorf, Germany. Kurt.Schneider@uni-duesseldorf.de
pubmed:publicationType
Journal Article, Review, Historical Article