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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-23
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pubmed:abstractText |
Human colorectal carcinomas display an infiltrative front of invasion where tumor cells undergo an epithelomesenchymal transition associated with low survival. Epithelomesenchymal transition is regulated by a nuclear beta-catenin accumulation, and subsequently, activation of beta-catenin/TCF4 target genes similar to CYCLIN D(1). Unexpectedly, these tumor cells are characterized by low proliferation, which correlates with the expression of the cell cycle inhibitor p16(INK4A). Therefore, we investigated the molecular mechanism of the transcriptional regulation of p16(INK4A) in colorectal cancer and its correlation with survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BrabletzThomasT,
pubmed-author:HaynlAngelaA,
pubmed-author:HiendlmeyerElkeE,
pubmed-author:HlubekFalkF,
pubmed-author:HorstDavidD,
pubmed-author:JungAndreasA,
pubmed-author:KirchnerThomasT,
pubmed-author:KrieglLydiaL,
pubmed-author:MerkelSusanneS,
pubmed-author:PalmqvistRichardR,
pubmed-author:ReuSimoneS,
pubmed-author:ScheelSilvio KSK,
pubmed-author:WassermannStellaS
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pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-205.e2
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18951899-Adult,
pubmed-meshheading:18951899-Aged,
pubmed-meshheading:18951899-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:18951899-Cell Line, Tumor,
pubmed-meshheading:18951899-Colorectal Neoplasms,
pubmed-meshheading:18951899-DNA-Binding Proteins,
pubmed-meshheading:18951899-Enhancer Elements, Genetic,
pubmed-meshheading:18951899-Female,
pubmed-meshheading:18951899-Gene Expression Regulation,
pubmed-meshheading:18951899-Genes, p16,
pubmed-meshheading:18951899-Humans,
pubmed-meshheading:18951899-Male,
pubmed-meshheading:18951899-Middle Aged,
pubmed-meshheading:18951899-Neoplasm Invasiveness,
pubmed-meshheading:18951899-Promoter Regions, Genetic,
pubmed-meshheading:18951899-Transcription Factors,
pubmed-meshheading:18951899-beta Catenin
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pubmed:year |
2009
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pubmed:articleTitle |
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
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pubmed:affiliation |
Pathologisch-Anatomisches Institut der Universität Erlangen-Nürnberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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