Source:http://linkedlifedata.com/resource/pubmed/id/18951020
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2008-11-13
|
| pubmed:abstractText |
A series of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors was discovered. Several compounds such as 15 and 20 showed good hNET potency. Compounds 15 and 20 also displayed excellent selectivity at hNET that appeared superior to those of reboxetine and atomoxetine (4 and 5).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6067-70
|
| pubmed:meshHeading |
pubmed-meshheading:18951020-Benzimidazoles,
pubmed-meshheading:18951020-Combinatorial Chemistry Techniques,
pubmed-meshheading:18951020-Drug Design,
pubmed-meshheading:18951020-Humans,
pubmed-meshheading:18951020-Molecular Structure,
pubmed-meshheading:18951020-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:18951020-Norepinephrine,
pubmed-meshheading:18951020-Stereoisomerism
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
|
| pubmed:affiliation |
Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ZhangP@wyeth.com
|
| pubmed:publicationType |
Journal Article
|