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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-26
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pubmed:abstractText |
Insulin resistance has a role in diabetic kidney complications. The K121Q (lysine to glutamine substitution at amino acid 121, encoded by single-nucleotide polymorphism rs1044498) variant of the ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) has been associated with insulin resistance and related vascular complications in patients with type 2 diabetes (T2D) in many, although not all, studies. This study investigated whether the ENPP1 Q121 variant modulates the risk of decreased glomerular filtration rate (GFR) in patients with T2D.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1523-6838
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pubmed:author |
pubmed-author:De CosmoSalvatoreS,
pubmed-author:DoriaAlessandroA,
pubmed-author:FiorettoPaolaP,
pubmed-author:MastroiannoSandraS,
pubmed-author:MinennaAntonioA,
pubmed-author:MiscioGiuseppeG,
pubmed-author:PellegriniFabioF,
pubmed-author:RauseoAnnaA,
pubmed-author:SallerAloisA,
pubmed-author:ThompsonRobertR,
pubmed-author:ThompsonRyanR,
pubmed-author:TrevisanRobertoR,
pubmed-author:TrischittaVincenzoV,
pubmed-author:VedovatoMonicaM,
pubmed-author:ZhangYuan-YuanYY
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-80
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pubmed:dateRevised |
2011-2-3
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pubmed:meshHeading |
pubmed-meshheading:18950909-Albuminuria,
pubmed-meshheading:18950909-Amino Acid Substitution,
pubmed-meshheading:18950909-Diabetes Mellitus, Type 2,
pubmed-meshheading:18950909-Female,
pubmed-meshheading:18950909-Glomerular Filtration Rate,
pubmed-meshheading:18950909-Humans,
pubmed-meshheading:18950909-Male,
pubmed-meshheading:18950909-Middle Aged,
pubmed-meshheading:18950909-Phosphoric Diester Hydrolases,
pubmed-meshheading:18950909-Polymorphism, Single Nucleotide,
pubmed-meshheading:18950909-Pyrophosphatases
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pubmed:year |
2009
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pubmed:articleTitle |
Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.
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pubmed:affiliation |
Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. sdecosm@tin.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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