| pubmed-article:18949559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18949559 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:18949559 | lifeskim:mentions | umls-concept:C0699733 | lld:lifeskim |
| pubmed-article:18949559 | lifeskim:mentions | umls-concept:C0876936 | lld:lifeskim |
| pubmed-article:18949559 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:18949559 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18949559 | pubmed:dateCreated | 2008-12-4 | lld:pubmed |
| pubmed-article:18949559 | pubmed:abstractText | Sepsis is a systemic response to infection characterized by increased production of inflammatory mediators including cytokines. Increased production of cytokines such as interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor (TNF) can have deleterious effects. Removal of cytokines via adsorption onto porous polymer substrates using an extracorporeal device may be a potential therapy for sepsis. We are developing a cytokine adsorption device (CAD) containing microporous polymer beads that will be used to decrease circulating levels of IL-6, TNF, and IL-10. In this paper we present a mathematical model of cytokine adsorption within such a device. The model accounts for macroscale transport through the device and internal diffusion and adsorption within the microporous beads. The analysis results in a simple analytic expression for the removal rate of individual cytokines that depends on a single cytokine-polymer specific parameter, Gamma( i ). This model was fit to experimental data and the value of Gamma( i ) was determined via nonlinear regression for IL-6, TNF, and IL-10. The model agreed well with the experimental data on the time course of cytokine removal. The model of the CAD and the values of Gamma( i ) will be applied in mathematical models of the inflammatory process and treatment of patients with sepsis. | lld:pubmed |
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| pubmed-article:18949559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18949559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18949559 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18949559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18949559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18949559 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18949559 | pubmed:issn | 1521-6047 | lld:pubmed |
| pubmed-article:18949559 | pubmed:author | pubmed-author:FederspielWil... | lld:pubmed |
| pubmed-article:18949559 | pubmed:author | pubmed-author:KellumJohn... | lld:pubmed |
| pubmed-article:18949559 | pubmed:author | pubmed-author:DiLeoMorgan... | lld:pubmed |
| pubmed-article:18949559 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18949559 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:18949559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18949559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18949559 | pubmed:pagination | 222-9 | lld:pubmed |
| pubmed-article:18949559 | pubmed:dateRevised | 2011-5-23 | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:meshHeading | pubmed-meshheading:18949559... | lld:pubmed |
| pubmed-article:18949559 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18949559 | pubmed:articleTitle | A simple mathematical model of cytokine capture using a hemoadsorption device. | lld:pubmed |
| pubmed-article:18949559 | pubmed:affiliation | McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA. | lld:pubmed |
| pubmed-article:18949559 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18949559 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18949559 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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