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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-4
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pubmed:abstractText |
Sepsis is a systemic response to infection characterized by increased production of inflammatory mediators including cytokines. Increased production of cytokines such as interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor (TNF) can have deleterious effects. Removal of cytokines via adsorption onto porous polymer substrates using an extracorporeal device may be a potential therapy for sepsis. We are developing a cytokine adsorption device (CAD) containing microporous polymer beads that will be used to decrease circulating levels of IL-6, TNF, and IL-10. In this paper we present a mathematical model of cytokine adsorption within such a device. The model accounts for macroscale transport through the device and internal diffusion and adsorption within the microporous beads. The analysis results in a simple analytic expression for the removal rate of individual cytokines that depends on a single cytokine-polymer specific parameter, Gamma( i ). This model was fit to experimental data and the value of Gamma( i ) was determined via nonlinear regression for IL-6, TNF, and IL-10. The model agreed well with the experimental data on the time course of cytokine removal. The model of the CAD and the values of Gamma( i ) will be applied in mathematical models of the inflammatory process and treatment of patients with sepsis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-10340175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-11373443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-11445675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-11800523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-11902250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-11940261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-12072677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-12398783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-12639085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-15090965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-15316198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-15385756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-15583478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-16471694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-17698689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-9230852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-9233726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-9359687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18949559-9875910
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1521-6047
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
222-9
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pubmed:dateRevised |
2011-5-23
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
A simple mathematical model of cytokine capture using a hemoadsorption device.
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pubmed:affiliation |
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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