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pubmed:abstractText |
QSAR models have been used to evaluate activities for compounds in the phenoxyphenyl-methanamine (PPMA) class of compounds. These models utilize Hammett-type donating-withdrawing substituent values as well as simple parameters to describe substituent size and elucidate the SAR of the 'A' and 'B' rings. Using this methodology, intuitive QSAR relationships were found for the three biological activities with R(2) values of 0.73, 0.45, and 0.58 for 5HT(2A), SerT, and hERG activities.
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pubmed:affiliation |
Pfizer Global Research and Development, Groton Laboratories, 1 Eastern Point Road, Groton, CT 06355, USA. scot.mente@pfizer.com
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