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pubmed:abstractText |
Persistent stimulation of cardiac beta1-adrenergic receptors by endogenous norepinephrine promotes heart failure progression. Polymorphisms of this gene are known to alter receptor function or expression, as are polymorphisms of the alpha 2C-adrenergic receptor, which regulates norepinephrine release from cardiac presynaptic nerves. The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients.
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pubmed:affiliation |
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St,, Ann Arbor, MI 48109-2029, USA. skardia@umich.edu
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