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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2009-2-20
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pubmed:abstractText |
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates,
http://linkedlifedata.com/resource/pubmed/chemical/FFAR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/G-protein-coupled receptor 40, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Gpr40 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BondAndrew DAD,
pubmed-author:ChristiansenElisabethE,
pubmed-author:DrewkeChristelC,
pubmed-author:HamacherAlexandraA,
pubmed-author:KarlsenKasper KKK,
pubmed-author:KassackMatthias UMU,
pubmed-author:KostenisEviE,
pubmed-author:LiebscherKathrinK,
pubmed-author:MertenNicoleN,
pubmed-author:SpinrathAndreasA,
pubmed-author:UllrichSusanneS,
pubmed-author:UlvenTrondT,
pubmed-author:UrbanChristianC
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7061-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18947221-Animals,
pubmed-meshheading:18947221-Cinnamates,
pubmed-meshheading:18947221-Crystallography, X-Ray,
pubmed-meshheading:18947221-Diabetes Mellitus, Type 2,
pubmed-meshheading:18947221-Dose-Response Relationship, Drug,
pubmed-meshheading:18947221-Drug Discovery,
pubmed-meshheading:18947221-Glucose,
pubmed-meshheading:18947221-Humans,
pubmed-meshheading:18947221-Insulin,
pubmed-meshheading:18947221-Mice,
pubmed-meshheading:18947221-Models, Molecular,
pubmed-meshheading:18947221-Molecular Structure,
pubmed-meshheading:18947221-Rats,
pubmed-meshheading:18947221-Receptors, G-Protein-Coupled,
pubmed-meshheading:18947221-Stereoisomerism,
pubmed-meshheading:18947221-Structure-Activity Relationship,
pubmed-meshheading:18947221-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.
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pubmed:affiliation |
Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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