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pubmed-article:18945995pubmed:abstractTextPatients with chronic kidney disease (CKD) receiving dialysis often develop secondary hyperparathyroidism with disturbed calcium and phosphorus metabolism. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (KDOQI) was established to guide treatment practices for these disorders. The ACHIEVE study was designed to test two treatment strategies for achieving KDOQI goals. DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: Individuals on hemodialysis treated with vitamin D sterols were enrolled in this 33-week study. Subjects were randomly assigned to treatment with either cinacalcet and low-dose vitamin D (Cinacalcet-D) or flexible vitamin D alone (Flex-D) to achieve KDOQI-recommended bone mineral targets. ACHIEVE included a 6-week screening phase, including vitamin D washout, a 16-week dose-titration phase, and an 11-week assessment phase.lld:pubmed
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pubmed-article:18945995pubmed:articleTitleCinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results.lld:pubmed
pubmed-article:18945995pubmed:affiliationWinthrop University Hospital, Department Of Nephrology, Mineola, New York 11501, USA. sfishbane@metrorenal.comlld:pubmed
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pubmed-article:18945995pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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