Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-11-12
pubmed:abstractText
Patients with chronic kidney disease (CKD) receiving dialysis often develop secondary hyperparathyroidism with disturbed calcium and phosphorus metabolism. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (KDOQI) was established to guide treatment practices for these disorders. The ACHIEVE study was designed to test two treatment strategies for achieving KDOQI goals. DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: Individuals on hemodialysis treated with vitamin D sterols were enrolled in this 33-week study. Subjects were randomly assigned to treatment with either cinacalcet and low-dose vitamin D (Cinacalcet-D) or flexible vitamin D alone (Flex-D) to achieve KDOQI-recommended bone mineral targets. ACHIEVE included a 6-week screening phase, including vitamin D washout, a 16-week dose-titration phase, and an 11-week assessment phase.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10480155, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10489228, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10692271, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10816185, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10845841, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10862640, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-10977787, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-11228177, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-11689387, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-11849407, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-11849871, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-12081584, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-12093777, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-12631365, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-12890843, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-14520607, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-14730504, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-15086935, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-17914251, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-18087055, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-7634548, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-8569985, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-8897570, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-8995749, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-9568825, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-9697664, http://linkedlifedata.com/resource/pubmed/commentcorrection/18945995-9708607
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1555-905X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1718-25
pubmed:dateRevised
2010-9-21
pubmed:meshHeading
pubmed-meshheading:18945995-Adult, pubmed-meshheading:18945995-Aged, pubmed-meshheading:18945995-Calcium, pubmed-meshheading:18945995-Chronic Disease, pubmed-meshheading:18945995-Drug Therapy, Combination, pubmed-meshheading:18945995-Female, pubmed-meshheading:18945995-Humans, pubmed-meshheading:18945995-Hyperparathyroidism, Secondary, pubmed-meshheading:18945995-Kidney Diseases, pubmed-meshheading:18945995-Male, pubmed-meshheading:18945995-Middle Aged, pubmed-meshheading:18945995-Naphthalenes, pubmed-meshheading:18945995-Parathyroid Hormone, pubmed-meshheading:18945995-Phosphorus, pubmed-meshheading:18945995-Practice Guidelines as Topic, pubmed-meshheading:18945995-Prospective Studies, pubmed-meshheading:18945995-Renal Dialysis, pubmed-meshheading:18945995-Time Factors, pubmed-meshheading:18945995-Treatment Outcome, pubmed-meshheading:18945995-Vitamin D, pubmed-meshheading:18945995-Vitamins
pubmed:year
2008
pubmed:articleTitle
Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results.
pubmed:affiliation
Winthrop University Hospital, Department Of Nephrology, Mineola, New York 11501, USA. sfishbane@metrorenal.com
pubmed:publicationType
Journal Article, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't