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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-2-6
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pubmed:abstractText |
The identification of novel factors regulating human T helper (Th)-cell differentiation into functionally distinct Th1 and Th2 subsets is important for understanding the mechanisms behind human autoimmune and allergic diseases. We have identified a protein of relevant evolutionary and lymphoid interest (PRELI), a novel protein that induces oxidative stress and a mitochondrial apoptosis pathway in human primary Th cells. We also demonstrated that PRELI inhibits Th2-cell development and down-regulates signal transducer and activator of transcription 6 (STAT6), a key transcription factor driving Th2 differentiation. Our data suggest that calpain, an oxidative stress-induced cysteine protease, is involved in the PRELI-induced down-regulation of STAT6. Moreover, we observed that a strong T-cell receptor (TCR) stimulus induces expression of PRELI and inhibits Th2 development. Our results suggest that PRELI is involved in a mechanism wherein the strength of the TCR stimulus influences the polarization of Th cells. This study identifies PRELI as a novel factor influencing the human primary Th-cell death and differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calpain,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRELID1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-0020
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1268-77
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18945965-Apoptosis,
pubmed-meshheading:18945965-Blotting, Western,
pubmed-meshheading:18945965-Calpain,
pubmed-meshheading:18945965-Cell Differentiation,
pubmed-meshheading:18945965-Cells, Cultured,
pubmed-meshheading:18945965-Cytokines,
pubmed-meshheading:18945965-Fetal Blood,
pubmed-meshheading:18945965-Fluorescent Antibody Technique,
pubmed-meshheading:18945965-Gene Expression Profiling,
pubmed-meshheading:18945965-Humans,
pubmed-meshheading:18945965-Infant, Newborn,
pubmed-meshheading:18945965-Kidney,
pubmed-meshheading:18945965-Lymphocyte Activation,
pubmed-meshheading:18945965-Membrane Potential, Mitochondrial,
pubmed-meshheading:18945965-Mitochondria,
pubmed-meshheading:18945965-Mitochondrial Proteins,
pubmed-meshheading:18945965-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18945965-Oxidative Stress,
pubmed-meshheading:18945965-Proteins,
pubmed-meshheading:18945965-RNA, Messenger,
pubmed-meshheading:18945965-Reactive Oxygen Species,
pubmed-meshheading:18945965-Receptors, Antigen, T-Cell,
pubmed-meshheading:18945965-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18945965-STAT6 Transcription Factor,
pubmed-meshheading:18945965-Signal Transduction,
pubmed-meshheading:18945965-Th1 Cells,
pubmed-meshheading:18945965-Th2 Cells
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pubmed:year |
2009
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pubmed:articleTitle |
PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation.
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pubmed:affiliation |
Turku Centre for Biotechnology, University of Turku and Abo Akademi, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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