Source:http://linkedlifedata.com/resource/pubmed/id/18945464
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2008-11-10
|
| pubmed:abstractText |
Liver transplantation (LT) in patients with hepatitis B virus (HBV) infection is associated with a high rate of graft loss and poor survival, unless re-infection can be prevented. Human hepatitis B immune globulin (HBIG) and nucleoside analogues (NA) have long been utilized to prevent re-infection. Previously, we generated a human monoclonal antibody (mAb), HB that recognizes the surface antigen of hepatitis B virus (HBV). We have constructed a secreted version of HB and cloned its genes into recombinant adeno-associated virus (AAV). We compared the efficiency of AAV vector after a single injection via intramuscular or intravenous routes without additional intervention. Then, we evaluated the activity of antibody HB in tree shrews treated with rAAV-HB and in vitro experiments. So, intramuscular injection of rAAV-HB was a suitable method for the immunoprophylaxis of HBV infection. This human antibody will be useful for the immunoprophylaxis of HBV infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1096-0341
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
5
|
| pubmed:volume |
382
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1-9
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| pubmed:meshHeading |
pubmed-meshheading:18945464-Amino Acid Sequence,
pubmed-meshheading:18945464-Animals,
pubmed-meshheading:18945464-Antibodies, Monoclonal,
pubmed-meshheading:18945464-Base Sequence,
pubmed-meshheading:18945464-Chemoprevention,
pubmed-meshheading:18945464-Dependovirus,
pubmed-meshheading:18945464-Gene Therapy,
pubmed-meshheading:18945464-Genetic Vectors,
pubmed-meshheading:18945464-Hepatitis B,
pubmed-meshheading:18945464-Hepatitis B Antibodies,
pubmed-meshheading:18945464-Hepatitis B virus,
pubmed-meshheading:18945464-Humans,
pubmed-meshheading:18945464-Liver Transplantation,
pubmed-meshheading:18945464-Mice,
pubmed-meshheading:18945464-Mice, Inbred C57BL,
pubmed-meshheading:18945464-Molecular Sequence Data,
pubmed-meshheading:18945464-Recurrence,
pubmed-meshheading:18945464-Tupaiidae
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
A novel approach of prophylaxis to HBV recurrence after liver transplantation.
|
| pubmed:affiliation |
Key Laboratory of Organ Transplantation, Ministry of Education/Ministry of Public Health, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|