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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033268,
umls-concept:C0185117,
umls-concept:C0205216,
umls-concept:C0333516,
umls-concept:C0596761,
umls-concept:C0597357,
umls-concept:C1123023,
umls-concept:C1179149,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-9
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pubmed:abstractText |
Skin immunosenescence accounts for increased susceptibility in the elderly to cutaneous infections and malignancies, and decreased contact hypersensitivity and response to vaccination. We have recently shown in immune cells that decreased expression of the receptor for activated C kinase (RACK)-1 underlies defective protein kinase C (PKC) activation and functional immune impairment with ageing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
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pubmed:issn |
1365-2133
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-25
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pubmed:meshHeading |
pubmed-meshheading:18945317-Age Factors,
pubmed-meshheading:18945317-Animals,
pubmed-meshheading:18945317-Cells, Cultured,
pubmed-meshheading:18945317-Epidermis,
pubmed-meshheading:18945317-Immunohistochemistry,
pubmed-meshheading:18945317-Male,
pubmed-meshheading:18945317-Protein Kinase C,
pubmed-meshheading:18945317-Rats,
pubmed-meshheading:18945317-Rats, Sprague-Dawley,
pubmed-meshheading:18945317-Receptors, Cell Surface,
pubmed-meshheading:18945317-Skin Aging,
pubmed-meshheading:18945317-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells.
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pubmed:affiliation |
Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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