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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
TNF-alpha and IL-1 have been associated with mucosal inflammation in both Crohn's disease (CD) and ulcerative colitis (UC). Innate immune defects have been associated with CD, specifically CARD15/NOD2. Recently, Toll-like receptor 8 (TLR8) signaling has been shown to enhance generation of both cytokines. Interestingly, TLR8 is located on the X chromosome and inflammatory bowel disease (IBD) has been associated with abnormalities of the X chromosome. The aim was to test whether TLR8 haplotypes are associated with IBD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18942751-10053016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18942751-10092301,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18942751-9734363
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1536-4844
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-7
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pubmed:dateRevised |
2011-5-4
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pubmed:meshHeading |
pubmed-meshheading:18942751-Chromosomes, Human, X,
pubmed-meshheading:18942751-Colitis, Ulcerative,
pubmed-meshheading:18942751-Crohn Disease,
pubmed-meshheading:18942751-DNA,
pubmed-meshheading:18942751-Female,
pubmed-meshheading:18942751-Genetic Diseases, X-Linked,
pubmed-meshheading:18942751-Genetic Predisposition to Disease,
pubmed-meshheading:18942751-Haplotypes,
pubmed-meshheading:18942751-Humans,
pubmed-meshheading:18942751-Immunity, Innate,
pubmed-meshheading:18942751-Intestinal Mucosa,
pubmed-meshheading:18942751-Male,
pubmed-meshheading:18942751-Polymorphism, Single Nucleotide,
pubmed-meshheading:18942751-Risk Factors,
pubmed-meshheading:18942751-Sex Chromosome Aberrations,
pubmed-meshheading:18942751-Sex Factors,
pubmed-meshheading:18942751-Toll-Like Receptor 8
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pubmed:year |
2009
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pubmed:articleTitle |
High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.
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pubmed:affiliation |
Inflammatory Bowel Disease Research Center, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California 90048, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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