Linked Life Data

18942138

Source:http://linkedlifedata.com/resource/pubmed/id/18942138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-11-3
pubmed:abstractText
The Vax2 homeobox gene plays a crucial role in early dorsoventral patterning of the eye. However, although Vax2 transcripts have been detected in later differentiating eye and brain regions, its possible roles at these stages are still unclear. By immunohistochemistry and in situ hybridization, we extensively compared the expression patterns of Xenopus Vax2 (Xvax2) mRNA and protein. Expression of Xvax2 protein was found to be largely overlapping but more restricted than that of mRNA, suggesting that Xvax2 expression may be also regulated at posttranscriptional levels. During eye and brain neurogenesis, Xvax2 protein was detected in proliferating neural progenitors and postmitotic differentiating cells in ventral regions of both structures. Overexpression of Xvax2 in Xenopus embryos by mRNA microinjection and DNA lipofection appeared to inhibit proliferation in both eye and brain cells, thus pointing to a new potential role for Vax2 in controlling the proliferative properties of ventral eye and brain progenitors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1058-8388
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2008 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
237
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3387-93
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A role for Xvax2 in controlling proliferation of Xenopus ventral eye and brain progenitors.
pubmed:affiliation
The State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't