Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-10-22
pubmed:abstractText
Human dendritic cells (DCs) are the main antigen presenting cells (APC) and can be divided into two main populations, myeloid and plasmacytoid DCs (pDCs), the latter being the main producers of Type I Interferon. The vast majority of pDCs can be found in lymphoid organs, where the main pool of all immune cells is located, but a minority of pDCs also circulate in peripheral blood. Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system. In this study, we could show that pDCs obtained from lymphoid organs (tonsils) (tpDCs) and from blood (bpDCs) are different subpopulations in humans. Interestingly, these populations react in opposite manner to HCMV-infection. TpDCs were fully permissive for HCMV. Their IFN-alpha production and the expression of costimulatory and adhesion molecules were altered after infection. In contrast, in bpDCs HCMV replication was abrogated and the cells were activated with increased IFN-alpha production and upregulation of MHC class I, costimulatory, and adhesion molecules. HCMV-infection of both, tpDCs and bpDCs, led to a decreased T cell stimulation, probably mediated through a soluble factor produced by HCMV-infected pDCs. We propose that the HCMV-mediated impairment of tpDCs is a newly discovered mechanism selectively targeting the host's major population of pDCs residing in lymphoid organs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-10225609, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-10589679, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-10644837, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11078019, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11209080, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11438475, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11489962, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11668340, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11713464, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11754820, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11854364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11875574, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-11929782, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-12358925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-12480251, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-12604816, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-12778470, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-12797453, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-1311364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-14962896, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15130499, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15159375, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15280480, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15322202, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15596797, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15771572, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-15941912, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-16210585, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-16269620, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-16426490, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-1658202, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-17450143, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-17646404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-17922015, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-17922016, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-18025223, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-18354207, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-2158627, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-2172831, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-7492764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-7622879, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-7835950, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-8041605, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-8057454, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-8625414, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-8876135, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9091583, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9095486, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9130040, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9130041, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9175839, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9287180, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9335340, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9480977, http://linkedlifedata.com/resource/pubmed/commentcorrection/18941519-9687534
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e3482
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Human cytomegalovirus impairs the function of plasmacytoid dendritic cells in lymphoid organs.
pubmed:affiliation
Department of Virology, Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't