Linked Life Data

18941205

Source:http://linkedlifedata.com/resource/pubmed/id/18941205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-10-22
pubmed:abstractText
EBV-induced gene 3 (EBI-3) codes for a soluble type I receptor homologous to the p40 subunit of IL-12 that is expressed by APCs following activation. In this study, we assessed the role of EBI-3 in a model of lung melanoma metastasis. Intravenous injection of the B16-F10 cell line resulted in a significant reduction of lung tumor metastasis in EBI-3(-/-) recipient mice compared with wild-type mice. The immunological finding accompanying this effect was the expansion of a newly described cell subset called IFN-gamma producing killer dendritic cells associated with CD8(+) T cell responses in the lung of EBI-3(-/-) mice including IFN-gamma release and TNF-alpha-induced programmed tumor cell death. Depletion of CD8(+) T cells as well as targeting T-bet abrogated the protective effects of EBI-3 deficiency on lung melanoma metastases. Finally, adoptive transfer of EBI-3(-/-) CD8(+) T cells into tumor bearing wild-type mice inhibited lung metastasis in recipient mice. Taken together, these data demonstrate that targeting EBI-3 leads to a T-bet-mediated antitumor CD8(+) T cell responses in the lung.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6148-57
pubmed:meshHeading
pubmed-meshheading:18941205-Animals, pubmed-meshheading:18941205-CD8-Positive T-Lymphocytes, pubmed-meshheading:18941205-Cell Line, Transformed, pubmed-meshheading:18941205-Cell Line, Tumor, pubmed-meshheading:18941205-Cell Transformation, Neoplastic, pubmed-meshheading:18941205-Cytotoxicity, Immunologic, pubmed-meshheading:18941205-Gene Knockout Techniques, pubmed-meshheading:18941205-Immunologic Surveillance, pubmed-meshheading:18941205-Injections, Intravenous, pubmed-meshheading:18941205-Lung Neoplasms, pubmed-meshheading:18941205-Melanoma, Experimental, pubmed-meshheading:18941205-Mice, pubmed-meshheading:18941205-Mice, Inbred C57BL, pubmed-meshheading:18941205-Mice, Knockout, pubmed-meshheading:18941205-Neoplasm Transplantation, pubmed-meshheading:18941205-Receptors, Cytokine, pubmed-meshheading:18941205-T-Box Domain Proteins
pubmed:year
2008
pubmed:articleTitle
Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.
pubmed:affiliation
Laboratory of Cellular and Molecular Immunology of the Lung, I. Medical Clinic, University of Mainz, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't