Source:http://linkedlifedata.com/resource/pubmed/id/18939960
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large cells with eccentrically located nuclei and deeply basophilic cytoplasm with a paranuclear hof. The tumour cells are invariably immunoreactive for the plasma cell marker CD138, and show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of the Ig light chain (IgL) gene expression in most of the cases. Similar to other types of AIDS-related lymphomas, there is evidence that Epstein-Barr virus and Kaposi-sarcoma associated Human Herpes Virus 8 may play a relevant role in the pathogenesis of PBL. PBL patients have been treated heterogeneously, with a combination of chemotherapy, radiotherapy and/or surgery, and their prognosis is usually poor, with a death rate of approximately 60% at 1 year.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
D
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1601-0825
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-45
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pubmed:meshHeading |
pubmed-meshheading:18939960-Epstein-Barr Virus Infections,
pubmed-meshheading:18939960-Gene Rearrangement,
pubmed-meshheading:18939960-Genes, Immunoglobulin Heavy Chain,
pubmed-meshheading:18939960-Genes, Immunoglobulin Light Chain,
pubmed-meshheading:18939960-Herpesvirus 8, Human,
pubmed-meshheading:18939960-Humans,
pubmed-meshheading:18939960-Lymphoma, AIDS-Related,
pubmed-meshheading:18939960-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:18939960-Mouth Neoplasms,
pubmed-meshheading:18939960-Sarcoma, Kaposi,
pubmed-meshheading:18939960-Syndecan-1
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pubmed:year |
2009
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pubmed:articleTitle |
Plasmablastic lymphoma: a review.
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pubmed:affiliation |
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Review
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