Source:http://linkedlifedata.com/resource/pubmed/id/18938093
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2009-6-30
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| pubmed:abstractText |
Antagonist at specific prostaglandin receptors might provide analgesia with a more favourable toxicity profile compared with cyclooxygenase inhibitors. We analyzed nociceptive responses in prostaglandin D, E, F, prostacyclin and thromboxane receptor knockout mice and mice deficient of cyclooxygenase 1 or 2 to evaluate the contribution of individual prostaglandin receptors for heat, mechanical and formalin-evoked pain. None of the knockouts was uniformly protected from all of these pain stimuli but COX-1 and EP4 receptor knockouts presented with reduced heat pain and EP3 receptor and COX-2 knockout mice had reduced licking responses in the 2nd phase of the formalin assay. This was accompanied with reduced c-Fos immunoreactivity in the spinal cord dorsal horn in EP3 knockouts. Oppositely, heat pain sensitivity was increased in FP, EP1 and EP1+3 double mutant mice possibly due to a loss of FP or EP1 receptor mediated central control of thermal pain sensitivity. Deficiency of either EP2 or DP1 was associated with increased formalin-evoked flinching responses and c-Fos IR in dorsal horn neurons suggesting facilitated spinal cord pain reflex circuity. Thromboxane and prostacyclin receptor knockout mice showed normal pain behavior in all tests. The results suggest a differential, pain-stimulus and site-specific contribution of specific PG-receptors for the processing of the nociceptive stimuli, a differential modulation of nociceptive responses by COX-1 and COX-2 derived prostaglandins and compensatory and/or developmental adaptations in mice lacking specific PG receptors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Formaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thromboxane,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin D2 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin F2alpha receptor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1532-2149
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
691-703
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| pubmed:meshHeading |
pubmed-meshheading:18938093-Animals,
pubmed-meshheading:18938093-Cyclooxygenase 1,
pubmed-meshheading:18938093-Cyclooxygenase 2,
pubmed-meshheading:18938093-Female,
pubmed-meshheading:18938093-Fluorescent Antibody Technique,
pubmed-meshheading:18938093-Formaldehyde,
pubmed-meshheading:18938093-Hot Temperature,
pubmed-meshheading:18938093-Image Processing, Computer-Assisted,
pubmed-meshheading:18938093-Male,
pubmed-meshheading:18938093-Mice,
pubmed-meshheading:18938093-Mice, Inbred C57BL,
pubmed-meshheading:18938093-Mice, Knockout,
pubmed-meshheading:18938093-Pain,
pubmed-meshheading:18938093-Pain Measurement,
pubmed-meshheading:18938093-Physical Stimulation,
pubmed-meshheading:18938093-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:18938093-Receptors, Epoprostenol,
pubmed-meshheading:18938093-Receptors, Immunologic,
pubmed-meshheading:18938093-Receptors, Prostaglandin,
pubmed-meshheading:18938093-Receptors, Prostaglandin E,
pubmed-meshheading:18938093-Receptors, Thromboxane
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| pubmed:year |
2009
|
| pubmed:articleTitle |
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
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| pubmed:affiliation |
pharmazentrum frankfurt, ZAFES, Institut für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universität Frankfurt, Theodor Stern Kai 7, Haus 74, Rm 437, 60590 Frankfurt am Main, Germany.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|