Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-24
pubmed:abstractText
BCM is a milk-derived peptide with opiate-like properties which is absorbed through the gastrointestinal mucosa. It has been shown to affect gastrointestinal motility, absorption and secretion. Recently, modulation of the immune system by BCM was also reported. In this study we investigated the in vitro effect of BCM on the human mucosal immune response as represented by lamina propria lymphocyte (LPL) proliferation. Results show that BCM significantly inhibited concanavalin A (ConA) stimulated LPL DNA synthesis. BCM also inhibited ornithine decarboxylase activity (ODC) in ConA-stimulated LPL. Although BCM also inhibited 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated LPL DNA synthesis, the degree of inhibition was much lower than in ConA-stimulated LPL. The anti-proliferative effect of BCM was reversed by the opiate receptor antagonist, neloxone. Our results suggest that BCM may affect the human mucosal immune system, possibly via the opiate receptor.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-195217, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-221578, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-224457, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-227959, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-2302978, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-2934481, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3005882, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3089867, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3102229, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3110101, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3156934, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-323291, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-3734964, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-4047342, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-4080604, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-4081127, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6117072, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6249313, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-626407, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6287475, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6294635, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6307570, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6320271, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6473168, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6548963, http://linkedlifedata.com/resource/pubmed/commentcorrection/1893631-6713744
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Beta-casomorphin (BCM) and human colonic lamina propria lymphocyte proliferation.
pubmed:affiliation
Department of Pediatrics, Wayne State University, Detroit, MI.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't