| pubmed-article:18936081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18936081 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:18936081 | lifeskim:mentions | umls-concept:C1538051 | lld:lifeskim |
| pubmed-article:18936081 | pubmed:issue | Pt 23 | lld:pubmed |
| pubmed-article:18936081 | pubmed:dateCreated | 2008-12-1 | lld:pubmed |
| pubmed-article:18936081 | pubmed:abstractText | Ligand-gated ion channels are activated by agonist binding, but may also be modulated by membrane voltage. N-Methyl-d-aspartate receptors (NMDARs) exhibit especially strong voltage dependence due to channel block by external Mg(2+) (Mg(o)(2+)). Here we demonstrate that activity of NMDARs composed of NR1 and NR2B subunits (NR1/2B receptors) is enhanced by depolarization even in 0 Mg(o)(2+), causing slow current relaxations in response to rapid voltage changes. We present a kinetic model of receptor activation that incorporates voltage-dependent gating-associated NR2B subunit conformational changes. The model accurately reproduces current relaxations during depolarizations and subsequent repolarizations in 0 Mg(o)(2+). Model simulations in physiological Mg(o)(2+) concentrations show that voltage-dependent receptor gating also underlies the slow component of Mg(o)(2+) unblock, a phenomenon that previously was shown to influence Mg(o)(2+) unblock kinetics during dendritic spikes. We propose that voltage-dependent gating of NR1/2B receptors confers enhanced voltage and time dependence on NMDAR-mediated signalling. | lld:pubmed |
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| pubmed-article:18936081 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18936081 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18936081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18936081 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18936081 | pubmed:issn | 1469-7793 | lld:pubmed |
| pubmed-article:18936081 | pubmed:author | pubmed-author:JohnsonJon... | lld:pubmed |
| pubmed-article:18936081 | pubmed:author | pubmed-author:ClarkeRichard... | lld:pubmed |
| pubmed-article:18936081 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18936081 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18936081 | pubmed:volume | 586 | lld:pubmed |
| pubmed-article:18936081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18936081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18936081 | pubmed:pagination | 5727-41 | lld:pubmed |
| pubmed-article:18936081 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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