Source:http://linkedlifedata.com/resource/pubmed/id/18932017
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2009-8-17
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pubmed:abstractText |
MicroRNA-21 (miR-21) is considered an onco-microRNA given its abilities to suppress the actions of several tumor suppressor genes and to promote tumor cell growth, invasion and metastasis. Recently, transforming growth factor-beta (TGF-beta) is found to up-regulate the expression of miR-21, and elevated miR-21 expression is seen frequently in breast cancer. To evaluate the effect of miR-21 on disease progression and its association with TGF-beta, we analyzed miR-21 expression in breast cancer. Fresh tumor samples were collected during surgery from 344 patients diagnosed with primary breast cancer. The expression of miR-21 in tumor samples was measured with a TaqMan microRNA assay using U6 as reference. Levels of miR-21 expression by disease stage, tumor grade, histology, hormone receptor status and lymph node involvement were compared. Cox proportional hazards regression analysis was performed to assess the association of miR-21 expression with disease-free and overall survival. The study results showed that the expression of miR-21 was detected in all tumor samples with substantial variation. High miR-21 expression was associated with features of aggressive disease, including high tumor grade, negative hormone receptor status, and ductal carcinoma. High miR-21 was also positively correlated with TGF-beta1. No associations were found between patient survival and miR-21 expression among all patients, but high miR-21 was associated with poor disease-free survival in early stage patients (HR = 2.08, 95% CI: 1.08-4.00) despite no value for prognosis. The study supports the notion that miR-21 is an onco-microRNA for breast cancer. Elevated miR-21 expression may facilitate tumor progression, and TGF-beta may up-regulate its expression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1573-7217
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18932017-Adult,
pubmed-meshheading:18932017-Aged,
pubmed-meshheading:18932017-Aged, 80 and over,
pubmed-meshheading:18932017-Breast Neoplasms,
pubmed-meshheading:18932017-Disease-Free Survival,
pubmed-meshheading:18932017-Female,
pubmed-meshheading:18932017-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18932017-Humans,
pubmed-meshheading:18932017-Kaplan-Meier Estimate,
pubmed-meshheading:18932017-MicroRNAs,
pubmed-meshheading:18932017-Middle Aged,
pubmed-meshheading:18932017-Neoplasm Staging,
pubmed-meshheading:18932017-Polymerase Chain Reaction,
pubmed-meshheading:18932017-Prognosis,
pubmed-meshheading:18932017-Proportional Hazards Models,
pubmed-meshheading:18932017-Transforming Growth Factor beta1,
pubmed-meshheading:18932017-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1.
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pubmed:affiliation |
Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
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pubmed:publicationType |
Journal Article
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