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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-30
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pubmed:abstractText |
The differential diagnosis of perineal biopsies can include squamous intraepithelial lesions, extramammary Paget's disease, and melanoma. Less frequently two of these lesions coexist. BD ProEx C is a recently developed immunoassay that targets expression of two genes shown to be associated with cervical cancer. Immunostaining for ProEx C has been validated in cervical cytology and positive staining has also been shown to be strongly associated with human papilloma virus (HPV)-induced cervical and anal intraepithelial neoplasia in biopsies. We observed positive staining for ProEx C in Paget cells in all of 26 cases of Paget's disease irrespective of tissue site (extramammary, mammary) and in melanoma cells in all of 12 cases of primary perineal melanoma with immunostaining in >50% of malignant cells in 73% of Paget disease cases and 43% of perineal melanoma cases. Positive staining was heterogeneous and exclusively nuclear in all cases. In situ hybridization was negative for low-risk and high-risk HPV subtypes in all Paget and melanoma cases that were tested. Currently neither of these lesions is known to be HPV related although according to the literature the possibility of a role for HPV in melanoma is still unsettled. Relevant literature is reviewed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II alpha,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MCM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Reagent Kits, Diagnostic
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1530-0285
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-51
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18931649-Adult,
pubmed-meshheading:18931649-Aged,
pubmed-meshheading:18931649-Aged, 80 and over,
pubmed-meshheading:18931649-Alphapapillomavirus,
pubmed-meshheading:18931649-Antigens, Neoplasm,
pubmed-meshheading:18931649-Anus Neoplasms,
pubmed-meshheading:18931649-Biopsy,
pubmed-meshheading:18931649-Cell Cycle Proteins,
pubmed-meshheading:18931649-DNA, Viral,
pubmed-meshheading:18931649-DNA Topoisomerases, Type II,
pubmed-meshheading:18931649-DNA-Binding Proteins,
pubmed-meshheading:18931649-Diagnosis, Differential,
pubmed-meshheading:18931649-Female,
pubmed-meshheading:18931649-Humans,
pubmed-meshheading:18931649-Immunoassay,
pubmed-meshheading:18931649-In Situ Hybridization,
pubmed-meshheading:18931649-Male,
pubmed-meshheading:18931649-Melanoma,
pubmed-meshheading:18931649-Middle Aged,
pubmed-meshheading:18931649-Mucous Membrane,
pubmed-meshheading:18931649-Nuclear Proteins,
pubmed-meshheading:18931649-Paget Disease, Extramammary,
pubmed-meshheading:18931649-Perineum,
pubmed-meshheading:18931649-Predictive Value of Tests,
pubmed-meshheading:18931649-Reagent Kits, Diagnostic,
pubmed-meshheading:18931649-Vaginal Neoplasms,
pubmed-meshheading:18931649-Vulvar Neoplasms
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pubmed:year |
2009
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pubmed:articleTitle |
BD ProEx C immunostaining in extramammary Paget's disease and perineal melanoma.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. walts@cshs.org
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pubmed:publicationType |
Journal Article
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