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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
23
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|
pubmed:dateCreated |
2008-11-13
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pubmed:abstractText |
In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic chalcones were assayed for their potential inhibitory action towards a protein tyrosine phosphatase from Mycobacterium tuberculosis--PtpA. The compounds were obtained by aldolic condensation between aldehydes and acetophenones, under basic conditions. Five compounds presented moderate or good activity. The structure-activity analysis reveals that the predominant factor for the activity is the molecule planarity/hydrophobicity and the nature of the substituents.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1464-3405
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
1
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|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6227-30
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|
pubmed:meshHeading |
|
|
pubmed:year |
2008
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|
pubmed:articleTitle |
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
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|
pubmed:affiliation |
Departamento de Química, Universidade Federal de Santa Catarina, Campus Trindade, 88040-900 Florianópolis, SC, Brazil.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
