Source:http://linkedlifedata.com/resource/pubmed/id/18930353
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-1-26
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pubmed:abstractText |
While considerable clinical evidence implicates thyroid hormones (THs) in depressive illness, the specific nature of this involvement remains unclear. The alpha1 subtype (TR-alpha1) is the most abundant TH receptor in brain. Here we investigated changes in TR-alpha1 mRNA in the chronic mild stress (CMS) model of depression. Rats were exposed to a CMS schedule for 3 weeks, which resulted in a progressive decreases in sucrose preference (an index of anhedonia). They were then treated daily with either imipramine (IMI, 10mg/kg) or vehicle (VEH) for 2 weeks before being sacrificed for quantitative in situ hybridization analyses of TR-alpha1 mRNA throughout the brain. Results indicated that CMS followed by VEH induced widespread decreases in TR-alpha1 mRNA in brain. In contrast, CMS-exposed rats receiving IMI for the last 2 weeks prior to sacrifice showed full recovery of sucrose preference. Furthermore, brain TR-alpha1 mRNA levels in these animals were similar to those of non-stressed controls receiving either SAL or IMI. These results reveal that TR-alpha1 mRNA brain levels are very sensitive to CMS effects. The reversal of both anhedonic and TR-alpha1 effects of CMS by IMI suggests that TR-alpha1 may play a role both in stress-induced depressive symptoms and in their reversal by antidepressant interventions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0306-4530
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-6
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pubmed:meshHeading |
pubmed-meshheading:18930353-Animals,
pubmed-meshheading:18930353-Antidepressive Agents,
pubmed-meshheading:18930353-Brain,
pubmed-meshheading:18930353-Imipramine,
pubmed-meshheading:18930353-Male,
pubmed-meshheading:18930353-RNA, Messenger,
pubmed-meshheading:18930353-Rats,
pubmed-meshheading:18930353-Rats, Wistar,
pubmed-meshheading:18930353-Stress, Physiological,
pubmed-meshheading:18930353-Stress, Psychological,
pubmed-meshheading:18930353-Thyroid Hormone Receptors alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Chronic mild stress induces widespread decreases in thyroid hormone alpha1 receptor mRNA levels in brain--reversal by imipramine.
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pubmed:affiliation |
Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ont., M5T 1R8 Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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