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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-11-17
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pubmed:abstractText |
In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the impact of sequence diversity in candidate genes involved in immunity (CTLA-4 and TNFalpha), in bile formation (10 hepatobiliary transporter genes) and in the adaptative response to cholestasis (three nuclear receptor genes) on the susceptibility and severity of PBC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/AE2 anion exchanger,
http://linkedlifedata.com/resource/pubmed/chemical/Anion Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antiporters,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Orphan Nuclear Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/liver X receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:BarbuVéroniqueV,
pubmed-author:ChazouillèresOlivierO,
pubmed-author:ChenPingP,
pubmed-author:ChrétienYvesY,
pubmed-author:CorpechotChristopheC,
pubmed-author:HeathSimon CSC,
pubmed-author:HoussetChantalC,
pubmed-author:MatsudaFumihikoF,
pubmed-author:PouponRaoulR,
pubmed-author:PouponRenée ERE,
pubmed-author:SimonTabassomeT
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1038-45
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18930330-Adult,
pubmed-meshheading:18930330-Aged,
pubmed-meshheading:18930330-Anion Transport Proteins,
pubmed-meshheading:18930330-Antigens, CD,
pubmed-meshheading:18930330-Antiporters,
pubmed-meshheading:18930330-CTLA-4 Antigen,
pubmed-meshheading:18930330-Case-Control Studies,
pubmed-meshheading:18930330-DNA-Binding Proteins,
pubmed-meshheading:18930330-Female,
pubmed-meshheading:18930330-France,
pubmed-meshheading:18930330-Genetic Predisposition to Disease,
pubmed-meshheading:18930330-Genetic Testing,
pubmed-meshheading:18930330-Humans,
pubmed-meshheading:18930330-Kaplan-Meier Estimate,
pubmed-meshheading:18930330-Liver Cirrhosis, Biliary,
pubmed-meshheading:18930330-Male,
pubmed-meshheading:18930330-Middle Aged,
pubmed-meshheading:18930330-Orphan Nuclear Receptors,
pubmed-meshheading:18930330-P-Glycoprotein,
pubmed-meshheading:18930330-Polymorphism, Single Nucleotide,
pubmed-meshheading:18930330-Prognosis,
pubmed-meshheading:18930330-Proportional Hazards Models,
pubmed-meshheading:18930330-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:18930330-Severity of Illness Index,
pubmed-meshheading:18930330-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Genetic factors of susceptibility and of severity in primary biliary cirrhosis.
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pubmed:affiliation |
UPMC University of Paris 06, UMRS_893, CdR Saint-Antoine, F-75012 Paris, France. raoul.poupon@sat.aphp.paris.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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