Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
52
pubmed:dateCreated
2008-12-1
pubmed:abstractText
The blood meal of hard ticks such as Ixodes ricinus lasts several days. This is made possible by tick salivary factors that inhibit inflammation, haemostasis and the host immune response. We assessed the latter on a model of immune response in vivo. A significant reduction of specific IgM and IgG levels was observed in BALB/c mice infested 5 days before injection with bovine serum albumin (BSA) and QuilA but not in mice infested 5 days after the immunization. This effect was not observed in mock-infested mice and could not be attributed to the use of anesthetics. The antibody response was not merely delayed and the Th(1)/Th(2) balance appeared not altered. T-dependent zones and germinal centers in lymph nodes draining the tick bite site showed no apparent morphological alterations or shift in T cell subpopulations. However, the spleens of tick-infested mice had also an enlarged red pulp, indicating an increased extramedullary haematopoietic activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6956-64
pubmed:meshHeading
pubmed-meshheading:18930098-Anesthetics, pubmed-meshheading:18930098-Animals, pubmed-meshheading:18930098-Antibody Formation, pubmed-meshheading:18930098-B-Lymphocytes, pubmed-meshheading:18930098-Cattle, pubmed-meshheading:18930098-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:18930098-Feeding Behavior, pubmed-meshheading:18930098-Female, pubmed-meshheading:18930098-Flow Cytometry, pubmed-meshheading:18930098-Immunoglobulin G, pubmed-meshheading:18930098-Immunoglobulin M, pubmed-meshheading:18930098-Immunohistochemistry, pubmed-meshheading:18930098-Immunologic Factors, pubmed-meshheading:18930098-Ixodes, pubmed-meshheading:18930098-Lymph Nodes, pubmed-meshheading:18930098-Lymphocyte Count, pubmed-meshheading:18930098-Male, pubmed-meshheading:18930098-Mice, pubmed-meshheading:18930098-Mice, Inbred BALB C, pubmed-meshheading:18930098-Salivary Glands, pubmed-meshheading:18930098-Serum Albumin, Bovine, pubmed-meshheading:18930098-Spleen, pubmed-meshheading:18930098-T-Lymphocytes, pubmed-meshheading:18930098-Tick Infestations
pubmed:year
2008
pubmed:articleTitle
Influence of the Ixodes ricinus tick blood-feeding on the antigen-specific antibody response in vivo.
pubmed:affiliation
Laboratory of Human Histology, University of Liege, Avenue de l'Hopital 1, B-4000 Liege, Belgium. C.Dedoyart@ulg.ac.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't