Source:http://linkedlifedata.com/resource/pubmed/id/18930089
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2008-11-21
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pubmed:abstractText |
Alpha-melanocyte-stimulating hormone (alpha-MSH) and its receptors are critical and indispensable for maintaining appropriate feeding behavior and energy homeostasis in both mice and humans. Corticotropin-releasing factor (CRF) is a candidate for mediating the anorexic effect of alpha-MSH. In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist. Intracerebroventricular administration of NDP-MSH, a synthetic alpha-MSH analogue, suppressed food intake in wild-type (WT) mice. This effect was abolished by pretreatment with a non-selective CRF receptor antagonist, astressin, suggesting that the effect of alpha-MSH-induced anorexia was mediated by a CRF receptor. In CRFKO mice, administration with NDP-MSH did not affect food intake at an early phase (0-4h). In addition, CRF mRNA levels in the hypothalamus were significantly increased in NDP-MSH-treated mice. Therefore, our findings, using CRFKO, strongly support evidence that CRF is involved in the acute anorexic effect of alpha-MSH. On the other hand, NDP-MSH administered to CRFKO mice led to suppressed food intake at the late phase (4-12h), similar to the effect in WT mice. Further, NDP-MSH similarly reduced food intake during the late phase in all types of mice, including WT, CRFKO, and CRFKO with corticosterone replacement. The results would suggest that alpha-MSH-induced suppression of food intake at late phase was independent of glucocorticoids and CRF.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/MSH, 4-Nle-7-Phe-alpha-,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-MSH,
http://linkedlifedata.com/resource/pubmed/chemical/astressin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0196-9781
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2169-74
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pubmed:meshHeading |
pubmed-meshheading:18930089-Animals,
pubmed-meshheading:18930089-Anorexia,
pubmed-meshheading:18930089-Corticosterone,
pubmed-meshheading:18930089-Corticotropin-Releasing Hormone,
pubmed-meshheading:18930089-Eating,
pubmed-meshheading:18930089-Hypothalamus,
pubmed-meshheading:18930089-Injections, Intraventricular,
pubmed-meshheading:18930089-Mice,
pubmed-meshheading:18930089-Mice, Knockout,
pubmed-meshheading:18930089-Peptide Fragments,
pubmed-meshheading:18930089-alpha-MSH
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pubmed:year |
2008
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pubmed:articleTitle |
Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice.
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pubmed:affiliation |
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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