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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
Thiazolidinedione ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), are used to treat diabetes. PPARgamma is highly expressed in the colon, and exposure to thiazolidinediones has been proposed to affect the risk for colorectal neoplasia. In vitro models suggest that thiazolidinediones have antineoplastic effects, whereas in vivo studies have produced mixed results: Some indicate an increased risk for intestinal tumors. This study examined the association between PPARgamma-targeted therapies and the risk of colonic neoplasia in patients with diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-10203281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-10393723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-10874062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-11138826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-11289109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-11491207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-11742490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-11950809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-12020332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-12370429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-12557142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-12621132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-12777356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-14522940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-15480982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-16136614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-16172212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-16288121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-16614119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-17192841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-17442990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-17603822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-17654746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-17896990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-7536208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9283786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9472692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9734398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9734399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9734400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930061-9887161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1914-23, 1923.e1
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18930061-Aged,
pubmed-meshheading:18930061-California,
pubmed-meshheading:18930061-Colonic Neoplasms,
pubmed-meshheading:18930061-Colonoscopy,
pubmed-meshheading:18930061-Diabetes Mellitus, Type 1,
pubmed-meshheading:18930061-Diabetes Mellitus, Type 2,
pubmed-meshheading:18930061-Female,
pubmed-meshheading:18930061-Follow-Up Studies,
pubmed-meshheading:18930061-Humans,
pubmed-meshheading:18930061-Hypoglycemic Agents,
pubmed-meshheading:18930061-Ligands,
pubmed-meshheading:18930061-Male,
pubmed-meshheading:18930061-Middle Aged,
pubmed-meshheading:18930061-Prevalence,
pubmed-meshheading:18930061-Questionnaires,
pubmed-meshheading:18930061-Retrospective Studies,
pubmed-meshheading:18930061-Risk Factors,
pubmed-meshheading:18930061-Thiazolidinediones
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pubmed:year |
2008
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pubmed:articleTitle |
Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitus.
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pubmed:affiliation |
Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. lewisjd@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Multicenter Study,
Research Support, N.I.H., Extramural
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