Linked Life Data

18928751

Source:http://linkedlifedata.com/resource/pubmed/id/18928751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-10-20
pubmed:abstractText
Bacterial translocation (BT) is defined as the passage of viable bacteria through the intestinal barrier toward the mesenteric lymph nodes, where they may disseminate toward other systems. The pathogenesis of BT in cirrhosis involves three main factors: bacterial overgrowth, increased intestinal permeability, and immune system alterations. Recent findings indicate that the concept of BT could be broadened to include the presence of bacterial products (bacterial DNA and endotoxin) in mesenteric lymph nodes and other territories. Both bacterial DNA and endotoxin provoke sustained activation of the immune system with release of proinflammatory cytokines and effectors such as nitric oxide, which aggravate the hemodynamic alterations present in patients with cirrhosis. This article provides a detailed description of the abnormalities present in patients with cirrhosis that allow the existence of TB and the immune and clinical repercussions of this phenomenon.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0210-5705
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
508-14
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Bacterial translocation in cirrhosis].
pubmed:affiliation
Unidad de Hepatología, Hospital General Universitario, Alicante, España.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't