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rdf:type |
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lifeskim:mentions |
umls-concept:C0032246,
umls-concept:C0449438,
umls-concept:C0456603,
umls-concept:C0524869,
umls-concept:C0752046,
umls-concept:C0936012,
umls-concept:C1283195,
umls-concept:C1510941,
umls-concept:C1514422,
umls-concept:C1704788,
umls-concept:C1707513,
umls-concept:C1710082
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pubmed:dateCreated |
2008-10-30
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pubmed:abstractText |
Genomic hybridization platforms, including BAC-CGH and genotyping arrays, have been used to estimate chromosome copy number (CN) in tumor samples by detecting the relative strength of genomic signal. The methods rely on the assumption that the predominant chromosomal background of the samples is diploid, an assumption that is frequently incorrect for tumor samples. In addition to generally greater resolution, an advantage of genotyping arrays over CGH arrays is the ability to detect signals from individual alleles, allowing estimation of loss-of-heterozygosity (LOH) and allelic ratios to enhance the interpretation of copy number alterations. Copy number events associated with LOH potentially have the same genetic consequences as deletions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-12042769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-14710948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-15120909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-15126342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-15588488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-16024607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-16124865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-16252233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-16899659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-16909388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-17044047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-17620294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-18050302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-6633649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18928532-9771718
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
489
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18928532-Allelic Imbalance,
pubmed-meshheading:18928532-Aneuploidy,
pubmed-meshheading:18928532-Gene Dosage,
pubmed-meshheading:18928532-Glioblastoma,
pubmed-meshheading:18928532-Humans,
pubmed-meshheading:18928532-Loss of Heterozygosity,
pubmed-meshheading:18928532-Nucleic Acid Hybridization,
pubmed-meshheading:18928532-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18928532-Ploidies,
pubmed-meshheading:18928532-Polymorphism, Single Nucleotide
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pubmed:year |
2008
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pubmed:articleTitle |
Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays.
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pubmed:affiliation |
Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, USA. paul_gardina@affymetrix.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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