Linked Life Data

18926883

Source:http://linkedlifedata.com/resource/pubmed/id/18926883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-11-25
pubmed:abstractText
We investigated episodic-like (ELM) and procedural memory (PM) in histamine H1 receptor knockout (H1R-KO) mice. In order to relate possible behavioral deficits to neurobiological changes, we examined H1R-KO and wild-type (WT) mice in terms of acetylcholine esterase (AChE) activity in subregions of the hippocampus and AChE and tyrosine hydroxylase (TH) expression in the striatum. Furthermore, we analyzed acetylcholine (ACh), 5-HT and dopamine (DA) levels, including metabolites, in the cerebellum of H1R-KO and WT mice. The homozygous H1R-KO mice showed impaired ELM as compared with the heterozygous H1R-KO and WT mice. The performance of homozygous H1R-KO mice in the ELM task was primarily driven by familiarity-based memory processes. While the homozygous H1R-KO mice performed similar to the heterozygous H1R-KO and WT mice during the acquisition of a PM, as measured with an accelerating rotarod, after a retention interval of 7 days their performance was impaired relative to the heterozygous H1R-KO and WT mice. These findings suggest that, both, ELM and long-term PM are impaired in the homozygous H1R-KO mice. Neurochemical assays revealed that the H1R-KO mice had significantly lower levels of AChE activity in the dentate gyrus (DG) and CA1 subregions of the hippocampus as compared with the WT mice. The homozygous H1R-KO mice also displayed significantly reduced dihydroxyphenylacetic acid (DOPAC) levels and a reduced DOPAC/DA ratio in the cerebellum, suggesting that the DA turnover in the cerebellum is decelerated in homozygous H1R-KO mice. In conclusion, homozygous H1R-KO mice display severe long-term memory deficits in, both, ELM and PM, which coincide with changes in AChE activity in the hippocampus as well as DA turnover in the cerebellum. The importance of these findings for Alzheimer's (AD) and Parkinson's disease (PD) is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
532-41
pubmed:meshHeading
pubmed-meshheading:18926883-3,4-Dihydroxyphenylacetic Acid, pubmed-meshheading:18926883-Acetylcholinesterase, pubmed-meshheading:18926883-Analysis of Variance, pubmed-meshheading:18926883-Animals, pubmed-meshheading:18926883-Behavior, Animal, pubmed-meshheading:18926883-Cerebellum, pubmed-meshheading:18926883-Conditioning, Operant, pubmed-meshheading:18926883-Dopamine, pubmed-meshheading:18926883-Gene Expression Regulation, pubmed-meshheading:18926883-Hippocampus, pubmed-meshheading:18926883-Male, pubmed-meshheading:18926883-Maze Learning, pubmed-meshheading:18926883-Memory Disorders, pubmed-meshheading:18926883-Mice, pubmed-meshheading:18926883-Mice, Inbred C57BL, pubmed-meshheading:18926883-Mice, Knockout, pubmed-meshheading:18926883-Receptors, Histamine H1, pubmed-meshheading:18926883-Tyrosine 3-Monooxygenase
pubmed:year
2008
pubmed:articleTitle
Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum.
pubmed:affiliation
Institute of Physiological Psychology, Center for Biological and Medical Research, Heinrich-Heine-University of Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany. dere@uni-duessedorf.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't