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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2008-11-13
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pubmed:abstractText |
'RNA bandages' are composed of two 6-12-mer 2'-OMe RNA strands complementary to a mRNA target that are joined by a photocleavable linker. These tandem oligonucleotides typically exhibit much higher affinity for the mRNA than the individual strands. An RNA bandage with binding arms of different lengths and a 4-base gap blocked translation in vitro of GFP mRNA; subsequent near-UV irradiation restored translation. This provides a general method of photomodulating hybridization for a variety of oligonucleotide-based technologies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-10409633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-11141065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-11300902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-11479592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-11926811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-12203979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15123812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15291544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15366887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15469235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15656605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-15869326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-16188439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-16213112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-16513347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17377650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17447773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17711280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17717538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17870546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-17951332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-18056083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-7984406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-8094959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18926697-9628915
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6255-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
RNA bandages for photoregulating in vitro protein synthesis.
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pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, 231 South 34th St., Philadelphia, PA 19104-6323, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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