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pubmed-article:18923910pubmed:abstractTextLymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.lld:pubmed
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pubmed-article:18923910pubmed:year2009lld:pubmed
pubmed-article:18923910pubmed:articleTitleProduction of biologically active human lymphotactin (XCL1) by Lactococcus lactis.lld:pubmed
pubmed-article:18923910pubmed:affiliationDepartamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.lld:pubmed
pubmed-article:18923910pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18923910pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed