|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-12-31
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|
pubmed:abstractText |
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1573-6776
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
215-20
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|
pubmed:meshHeading |
|
|
pubmed:year |
2009
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|
pubmed:articleTitle |
Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis.
|
|
pubmed:affiliation |
Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
