Source:http://linkedlifedata.com/resource/pubmed/id/18923570
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2008-10-16
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| pubmed:abstractText |
One bout of exercise enhances insulin-stimulated glucose uptake (insulin action), but the effect is blunted by consumption of carbohydrate-containing food after exercise. The independent roles of energy and carbohydrate in mediating post-exercise insulin action have not been systematically evaluated in humans. The purpose of this study was to determine if varying carbohydrate availability, with energy intake held constant, mediates post-exercise insulin action. Ten young (21 +/- 2 y, overweight (body fat 37% +/- 3%) men and women completed 3 conditions in random order: (i) no-exercise (BASE), (ii) exercise with energy balance but carbohydrate deficit (C-DEF), and (iii) exercise with energy and carbohydrate balance (C-BAL). In the exercise conditions, subjects expended 30% of total daily energy expenditure on a cycle ergometer at 70% VO2 peak. Following exercise, subjects consumed a meal that replaced expended energy (~3000 kJ) and was either balanced (intake = expenditure) or deficient (-100 g) in carbohydrate. Twelve hours later, insulin action was measured by continuous infusion of glucose with stable isotope tracer (CIG-SIT). Changes in insulin action were evaluated using a one-way ANOVA with repeated measures. During CIG-SIT, non-oxidative glucose disposal (i.e., glucose storage) was higher in C-DEF than in BASE (27.2 +/- 3.2 vs. 16.9 +/- 3.5 micromol.L-1.kg-1.min-1, p < 0.05). Conversely, glucose oxidation was lower in C-DEF (8.6 +/- 1.3 micromol.L-1.kg-1.min-1) compared with C-BAL (12.2 +/- 1.2 micromol.L-1.kg-1.min-1), and BASE (17.1 +/- 2.2 micromol.L-1.kg-1.min-1), p < 0.05). Fasting fat oxidation was higher in C-DEF than in BASE (109.8 +/- 10.5 vs. 80.7 +/- 9.6 mg.min-1, p < 0.05). In C-DEF, enhanced insulin action was correlated with the magnitude of the carbohydrate deficit (r = 0.82, p < 0.01). Following exercise, re-feeding expended energy, but not carbohydrate, increased fasting fat oxidation, and shifted insulin-mediated glucose disposal toward increased storage and away from oxidation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1715-5312
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
33
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
946-56
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18923570-Algorithms,
pubmed-meshheading:18923570-Area Under Curve,
pubmed-meshheading:18923570-Blood Glucose,
pubmed-meshheading:18923570-Body Composition,
pubmed-meshheading:18923570-Carbohydrate Metabolism,
pubmed-meshheading:18923570-Dietary Carbohydrates,
pubmed-meshheading:18923570-Energy Intake,
pubmed-meshheading:18923570-Energy Metabolism,
pubmed-meshheading:18923570-Exercise,
pubmed-meshheading:18923570-Exercise Test,
pubmed-meshheading:18923570-Female,
pubmed-meshheading:18923570-Glucose,
pubmed-meshheading:18923570-Humans,
pubmed-meshheading:18923570-Insulin,
pubmed-meshheading:18923570-Lipid Metabolism,
pubmed-meshheading:18923570-Male,
pubmed-meshheading:18923570-Obesity,
pubmed-meshheading:18923570-Oxidation-Reduction,
pubmed-meshheading:18923570-Young Adult
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| pubmed:year |
2008
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| pubmed:articleTitle |
The effect of carbohydrate availability following exercise on whole-body insulin action.
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| pubmed:affiliation |
Energy Metabolism Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, USA.
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|