Source:http://linkedlifedata.com/resource/pubmed/id/18923565
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-10-16
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| pubmed:abstractText |
To investigate the ameliorative potential of sodium selenite and zinc sulfate on intensive-swimming-induced testicular disorders, 48 Wistar male rats (age, 4 months; mass, 146.2 +/- 3.6 g) were randomly divided into 4 groups: the unexercised-control group (n = 12); the exercised group (n = 12); the control supplemented group (n = 12); and the exercised supplemented group (n = 12). For 10 weeks, the exercised rats underwent a protocol that consisted of 4 h.d-1 swimming, for 6 d.week-1; the control rats did not exercise. For 10 weeks, both the supplemented groups received an oral daily dose of a combination of sodium selenite and zinc sulfate (6 and 3 mg.kg body mass-1, respectively). After 10 weeks, a significant reduction (p < 0.05) was seen in rats in the exercised group, compared with rats in both control groups, in paired testicular masses; in epididymal sperm count; in testicular Delta5, 3beta-hydroxysteroid dehydrogenase (HSD) and 17beta-HSD; in plasma levels of testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin; in the numbers of preleptotine spermatocytes, midpachytene spermatocytes, and stage 7 spermatids of the stage VII seminiferous epithelium cycle; and in fertility performance. As well, a significant increase (p < 0.05) was seen in the exercised group, compared with both control groups, in plasma corticosterone levels and in testicular content of malondialdehyde and catalase activity. At the same time, there was a significant reduction (p < 0.05) in the exercised group, compared with both control groups, in plasma concentrations of zinc and selenium; in the testicular content of glutathione (GSH), the glutathione and glutathione disulphide (GSSG) ratio, ascorbic acid, and alpha-tocopherol; and in testicular activities of superoxide dismutase, glutathione-peroxidase, and glutathione-S-transferase in the testes. No significant changes were seen in the number of spermatogonia-A from the stage VII seminiferous epithelium cycle or the testicular content of GSSG among the groups. Sodium selenite and zinc sulfate supplementation significantly protected against exercise-induced testicular gamatogenic and spermatogenic disorders, prevented testicular oxidative stress, and increased antioxidant status. It can be concluded that intensive-swimming-induced oxidative stress causes dysfunctions in the male reproductive system, which can be protected by the coadministration of sodium selenite and zinc sulfate.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Selenite,
http://linkedlifedata.com/resource/pubmed/chemical/Steroids,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc Sulfate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1715-5312
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
903-14
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| pubmed:meshHeading |
pubmed-meshheading:18923565-Animals,
pubmed-meshheading:18923565-Corticosterone,
pubmed-meshheading:18923565-Epididymis,
pubmed-meshheading:18923565-Fertility,
pubmed-meshheading:18923565-Follicle Stimulating Hormone,
pubmed-meshheading:18923565-Gametogenesis,
pubmed-meshheading:18923565-Hormones,
pubmed-meshheading:18923565-Lipid Peroxidation,
pubmed-meshheading:18923565-Luteinizing Hormone,
pubmed-meshheading:18923565-Male,
pubmed-meshheading:18923565-Organ Size,
pubmed-meshheading:18923565-Oxidative Stress,
pubmed-meshheading:18923565-Prolactin,
pubmed-meshheading:18923565-Rats,
pubmed-meshheading:18923565-Rats, Wistar,
pubmed-meshheading:18923565-Sodium Selenite,
pubmed-meshheading:18923565-Sperm Count,
pubmed-meshheading:18923565-Spermatogenesis,
pubmed-meshheading:18923565-Steroids,
pubmed-meshheading:18923565-Swimming,
pubmed-meshheading:18923565-Testicular Diseases,
pubmed-meshheading:18923565-Testis,
pubmed-meshheading:18923565-Testosterone,
pubmed-meshheading:18923565-Zinc Sulfate
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| pubmed:year |
2008
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| pubmed:articleTitle |
Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats.
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| pubmed:affiliation |
Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA.
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| pubmed:publicationType |
Journal Article
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