rdf:type |
|
lifeskim:mentions |
umls-concept:C0007765,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0030705,
umls-concept:C0036341,
umls-concept:C0185117,
umls-concept:C0205349,
umls-concept:C0441655,
umls-concept:C0596630,
umls-concept:C1314939,
umls-concept:C1521797,
umls-concept:C2911684
|
pubmed:issue |
12
|
pubmed:dateCreated |
2008-12-2
|
pubmed:abstractText |
Deficits in gamma-aminobutyric acid (GABA) signaling have been described in the prefrontal cortex, limbic system, and cerebellum in individuals with schizophrenia. The purpose of the present study was to further investigate cerebellar gene expression alterations as they relate to decreases in GABAergic transmission by examining the expression of GABAergic markers, N-methyl-d-aspartic-acid (NMDA) receptor subunits, and cerebellum neuromodulators in individuals with schizophrenia.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
1535-7228
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
165
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1594-603
|
pubmed:dateRevised |
2009-4-16
|
pubmed:meshHeading |
pubmed-meshheading:18923069-Adult,
pubmed-meshheading:18923069-Aged,
pubmed-meshheading:18923069-Cerebellum,
pubmed-meshheading:18923069-Gene Expression,
pubmed-meshheading:18923069-Glutamate Decarboxylase,
pubmed-meshheading:18923069-Granulocytes,
pubmed-meshheading:18923069-Humans,
pubmed-meshheading:18923069-Male,
pubmed-meshheading:18923069-Middle Aged,
pubmed-meshheading:18923069-Neurotransmitter Agents,
pubmed-meshheading:18923069-RNA, Messenger,
pubmed-meshheading:18923069-Receptors, GABA-A,
pubmed-meshheading:18923069-Schizophrenia,
pubmed-meshheading:18923069-Synaptic Transmission,
pubmed-meshheading:18923069-gamma-Aminobutyric Acid
|
pubmed:year |
2008
|
pubmed:articleTitle |
Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients.
|
pubmed:affiliation |
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|