Linked Life Data

18922975

Source:http://linkedlifedata.com/resource/pubmed/id/18922975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-10-16
pubmed:abstractText
Bone morphogenetic proteins (BMP) have been implicated in the development of bone metastases in prostate cancer. In this study, we investigated the role which BMP-9 played in prostate cancer and found that the expression of BMP-9 was decreased or absent in prostate cancer, particularly in the foci of higher grade disease. We further investigated the influence of BMP-9 on the biological behaviors of prostate cancer cells. The forced overexpression of BMP-9 prevented the in vitro growth, cell-matrix adhesion, invasion, and migration of prostate cancer cells. We also elucidated that BMP-9 induced apoptosis in PC-3 cells through the up-regulation of prostate apoptosis response-4. Among the receptors which have been implicated in the signaling of BMP-9, BMPR-IB and BMPR-II have also been implicated in the development and progression of prostate cancer. Knockdown of BMPR-IB or BMPR-II using respective hammerhead ribozyme transgenes could promote cell growth in vitro. We also found that BMPR-II is indispensable for the Smad-dependent signal transduction by BMP-9 in PC-3 cells, in which Smad-1 was phosphorylated and translocated from the cytoplasm into the nuclei. Taken together, BMP-9 inhibits the growth of prostate cancer cells due to the induced apoptosis, which is related to an up-regulation of prostate apoptosis response-4 through a Smad-dependent pathway. BMP-9 could also prevent the migration and invasiveness of prostate cancer. This suggests that BMP-9 may function as a tumor suppressor and apoptosis regulator in prostate cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1541-7786
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1594-606
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18922975-Apoptosis, pubmed-meshheading:18922975-Apoptosis Regulatory Proteins, pubmed-meshheading:18922975-Bone Morphogenetic Protein Receptors, Type I, pubmed-meshheading:18922975-Bone Morphogenetic Protein Receptors, Type II, pubmed-meshheading:18922975-Bone Morphogenetic Proteins, pubmed-meshheading:18922975-Cell Line, Tumor, pubmed-meshheading:18922975-Cell Proliferation, pubmed-meshheading:18922975-Gene Expression Regulation, Neoplastic, pubmed-meshheading:18922975-Growth Differentiation Factor 2, pubmed-meshheading:18922975-Growth Differentiation Factors, pubmed-meshheading:18922975-Humans, pubmed-meshheading:18922975-Male, pubmed-meshheading:18922975-Models, Biological, pubmed-meshheading:18922975-Prostate, pubmed-meshheading:18922975-Prostatic Neoplasms, pubmed-meshheading:18922975-Signal Transduction, pubmed-meshheading:18922975-Smad Proteins
pubmed:year
2008
pubmed:articleTitle
Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4.
pubmed:affiliation
Metastasis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, United Kingdom. Yel@cf.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't