Source:http://linkedlifedata.com/resource/pubmed/id/18922529
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-5-4
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| pubmed:abstractText |
Large increases in inflammatory markers, particularly IL-6, occur after cardiac surgery. However, despite interventions to reduce the inflammatory response, great variability still remains which could in part be attributable to genetic predisposition. Since increased IL-6 levels following surgery are also associated with poorer outcome we sought to determine whether baseline and post-operative levels of Interleukin-6 (IL-6) and functional common variants of the Interleukin-6 (IL6) gene are associated with post-operative outcome following coronary artery bypass grafting (CABG). Caucasian patients undergoing first-time elective CABG were studied. IL-6 levels were measured pre-, 6h and 24h following surgery and genotypes for IL6 gene variants -174G>C and -572G>C were obtained. Clinical data was collected daily until patient discharge. Patient outcome was categorised as with (ICUC, n=177) and without (NICUC, n=189) a post-operative complication during the ICU period and with (POC, n=215) and without (NC, n=151) a post-operative complication during hospitalisation. IL-6 levels pre- and at 24h were greater in POC and ICUC than NC and NICUC, respectively. Pre- IL-6 levels independently predicted (for 1 standard deviation increase in log IL-6) POC (OR 1.4, 95% CI 1.1-1.7, p=0.008) and ICUC (OR 1.3, 95% CI 1.0-1.6, p=0.02) outcomes. Overall, the IL6-572G>C had an effect over time on IL-6 levels (p=0.04) and on IL-6 levels in NC (P=0.008) and NICUC (p=0.006). However, no associations were found with the IL6 -572G>C or -174G>C variants on IL-6 levels at individual time-points or by outcome group. Thus, in conclusion, elevated pre-operative IL-6 levels, but not IL6 gene variants predict poor patient outcome following CABG.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1879-1484
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
204
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
196-201
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| pubmed:meshHeading |
pubmed-meshheading:18922529-Aged,
pubmed-meshheading:18922529-Biological Markers,
pubmed-meshheading:18922529-Coronary Artery Bypass,
pubmed-meshheading:18922529-European Continental Ancestry Group,
pubmed-meshheading:18922529-Female,
pubmed-meshheading:18922529-Genetic Predisposition to Disease,
pubmed-meshheading:18922529-Humans,
pubmed-meshheading:18922529-Inflammation,
pubmed-meshheading:18922529-Interleukin-6,
pubmed-meshheading:18922529-Logistic Models,
pubmed-meshheading:18922529-Male,
pubmed-meshheading:18922529-Middle Aged,
pubmed-meshheading:18922529-Phenotype,
pubmed-meshheading:18922529-Polymorphism, Genetic,
pubmed-meshheading:18922529-Predictive Value of Tests,
pubmed-meshheading:18922529-Prospective Studies,
pubmed-meshheading:18922529-Risk Assessment,
pubmed-meshheading:18922529-Risk Factors,
pubmed-meshheading:18922529-Surgical Procedures, Elective,
pubmed-meshheading:18922529-Time Factors,
pubmed-meshheading:18922529-Treatment Outcome,
pubmed-meshheading:18922529-Up-Regulation
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| pubmed:year |
2009
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| pubmed:articleTitle |
Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.
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| pubmed:affiliation |
Department of Surgery, University College London, London, UK. j.sanders@ucl.ac.uk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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