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rdf:type |
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lifeskim:mentions |
umls-concept:C0005390,
umls-concept:C0016059,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0458827,
umls-concept:C1120843,
umls-concept:C1366876,
umls-concept:C1521761,
umls-concept:C1711178,
umls-concept:C1819425,
umls-concept:C1879547,
umls-concept:C1880177
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pubmed:issue |
7
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
Bile acid aspiration occurs in a variety of acute and chronic airway disorders. The consequence of bile acid aspiration and lung disease remains unclear. It was hypothesized that airway epithelium exposure to bile acids would induce fibrosis via production of connective tissue growth factor (CCN2), CCN2 is essential for transforming growth factor-beta (TGFbeta)-induced fibrogenesis and functions as a downstream mediator of TGF-beta action on fibroblasts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bile Acids and Salts,
http://linkedlifedata.com/resource/pubmed/chemical/CTGF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1440-1843
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
983-9
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pubmed:dateRevised |
2010-3-23
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pubmed:meshHeading |
pubmed-meshheading:18922143-Activating Transcription Factor 2,
pubmed-meshheading:18922143-Bile Acids and Salts,
pubmed-meshheading:18922143-Blotting, Western,
pubmed-meshheading:18922143-Bronchi,
pubmed-meshheading:18922143-Cells, Cultured,
pubmed-meshheading:18922143-Connective Tissue Growth Factor,
pubmed-meshheading:18922143-Dexamethasone,
pubmed-meshheading:18922143-Enzyme Activation,
pubmed-meshheading:18922143-Enzyme Inhibitors,
pubmed-meshheading:18922143-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18922143-Fibrosis,
pubmed-meshheading:18922143-Gene Expression,
pubmed-meshheading:18922143-Glucocorticoids,
pubmed-meshheading:18922143-Humans,
pubmed-meshheading:18922143-Imidazoles,
pubmed-meshheading:18922143-Phosphorylation,
pubmed-meshheading:18922143-Pyridines,
pubmed-meshheading:18922143-RNA, Messenger,
pubmed-meshheading:18922143-Respiratory Mucosa,
pubmed-meshheading:18922143-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18922143-Transforming Growth Factor beta1,
pubmed-meshheading:18922143-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
Bile acids induce CCN2 production through p38 MAP kinase activation in human bronchial epithelial cells: a factor contributing to airway fibrosis.
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pubmed:affiliation |
1Department of Chest Medicine,3School of Medicine, National Yang-Ming University, Taipei, Taiwan. dwperng@vghtpe.gov.tw
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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