Linked Life Data

18922122

Source:http://linkedlifedata.com/resource/pubmed/id/18922122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-10-16
pubmed:abstractText
The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma. Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1744-8301
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
647-60
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.
pubmed:affiliation
Département Endocrinologie Métabolisme et Cancer, Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't