Linked Life Data

1892196

Source:http://linkedlifedata.com/resource/pubmed/id/1892196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-16
pubmed:abstractText
The effects of cigarette smoking on maternal airway function during pregnancy were investigated in a cross-sectional study of 97 smokers and 175 nonsmokers at different gestational ages. The groups were comparable in age, height, and weight. All subjects were healthy. Forced vital capacity, forced expiratory volume in 1 second, their ratio, the forced expiratory flow rates between 0.2 and 1.2 L, 25% and 75%, and 75% and 85%, and instantaneous flows at lung volumes of 25%, 50%, and 75% were measured. All spirometric tests were unaffected by gestational age. However, all parameters of spirometry were significantly less in smokers than in nonsmokers when cumulative data during pregnancy were compared. Forced vital capacity, forced expiratory volume in 1 second, and their ratio were minimally reduced (4%, p less than 0.05; 8%, p less than 0.001; and 4%, p less than 0.001; respectively) in smokers as compared with nonsmokers. Larger reductions were noted in forced expiratory flow rates between 0.2 and 1.2 L (14%, p less than 0.001) and between 25% and 75% (16%, p less than 0.001), and in instantaneous maximum flows at lung volumes of 75% (11%, p less than 0.001) and 50% (13%, p less than 0.001). Maximum reduction of forced expiratory flow rates between 75% and 85% (26%, p less than 0.001) and in instantaneous flows at maximum lung volumes of 25% (23%, p less than 0.001) suggests marked increases in small-airway resistance and early small-airway disease in smokers. The progression of small-airway disease is related to the level of cigarette exposure. The results of our study demonstrate that the bronchodilatory effect expected in pregnancy is not sufficient to overcome the deleterious effects of cigarette smoking.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effect of cigarette smoking on maternal airway function during pregnancy.
pubmed:affiliation
Department of Obstetrics and Gynecology, Saint-François D'Assise Hospital, Laval University, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't